in textile processing and serves as an intermediary product in the chemical industry. [58], In July 2007, health authorities in the UK detected a counterfeit Sensodyne toothpaste on sale at a car boot sale in Derbyshire. The resulting product is two ethylene glycol molecules joined by an ether bond. • As a structural component of various liquid crystals. Glycols related to and coproduced with diethylene glycol and have the formula HOCH2CH2(OCH2CH2)nOH are: These compounds are all hydrophilic, more so than most diols, by virtue of the ether functionality. 14th ed. Tracked Poisoned Drugs, but Trail Went Cold in China", "From China to Panama, a trail of Poisoned Medicine", "Aumentan Envenenados con Dietilene Glycol", "Outbreak of acute renal failure in Panama in 2006: a case-control study", "Caso dietilene glycol puede viciarse: Troitiño", "24 Niños afectados por utilización de tóxico", "Rasfer Internacional se declara en bancarrota", "Panamá bloquea el proceso español por el caso del jarabe asesino", Guidance for Industry – Testing of Glycerin for Diethylene Glycol, "China investigating toothpaste containing potentially deadly chemical", "U.S. checking all toothpaste imports from China", "7online.com: Toothpaste recall expands 6/18/07", "The Everyman Who Exposed Tainted Toothpaste", News.yahoo.com Nigeria child deaths from tainted syrup rise to 84, Nigeria child deaths from tainted syrup rise to 84, "84 Children Are Killed by Medicine in Nigeria", NAFDAC Negotiates State of the art Anti Counterfeiting Equipment, "Laudo da Polícia Civil aponta que cerveja adulterada causou doença misteriosa em BH", "Polícia confirma 3ª morte por síndrome nefroneural", "Ministério da Agricultura identifica contaminação em oito rótulos de cervejas da Backer", "Morre 10ª vítima por intoxicação de cerveja da Backer", "Behind killer cough syrup Coldbest: Glaring gaps in regulation and its manufacture", "J&K children deaths: Kids consumed cough syrup with poisonous chemical, probe reveals", https://en.wikipedia.org/w/index.php?title=Diethylene_glycol&oldid=998487761, Articles with dead external links from July 2019, Articles with permanently dead external links, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles containing Chinese-language text, Creative Commons Attribution-ShareAlike License, 244 to 245 °C (471 to 473 °F; 517 to 518 K), This page was last edited on 5 January 2021, at 16:24. The outbreak forced the government to ban the sale of paracetamol elixirs in December 1992, causing a decline of 53% in the admission of patients with kidney failure and an 84% decline in admissions by unexplained kidney failure. The LD50 for small mammals has been tested at between 2 and 25 g/kg, less toxic than its relative ethylene glycol, but still capable of causing toxicity in humans. Further investigation revealed all patients were treated with topical silver sulfadiazine ointment that contained 7 g/kg of DEG. [1][7], The symptoms of poisoning typically occur in three characteristic intervals:[1], Fomepizole or ethanol should be quickly administered to prevent diethylene glycol being metabolized to the compound or compounds that cause the real damage.[1]. Mr. Wang was caught and Qiquihar was shut down by the authorities. [38], Ending June 1996, the FDA had discovered counterfeit glycerin traced back to Chemical Trading and Consulting (a German broker), which bought 72 barrels of the syrup from Vos B.V., a Dutch company. The fiscal attorney urged affected citizens to approach the Public Ministry to update the official legal file and for further medical analysis. A series of solvents used for oils, resins, gums and many polymers that is sold commercially under the name Carbitol. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Later, raw glycerin was analyzed and results revealed 22.2% v/v DEG. U.S. Food and Drug Administration Press Release. [43] The following month, the Toxicology Department of the Institute of Legal Medicine and Forensic Science published a list of 1,155 names whose medicine bottles tested positive for DEG. [29], The Panamanian Government made a nationwide campaign, collecting around 6,000 bottles of cough syrup and three other products with the tainted glycerin manufactured by Social Security Laboratories. During the month of July 1985, Austrian wines were found to contain up to 1,000 parts per million of DEG, giving them a desirable sweetness. They react with oxoacids and carboxylic acids to … CS1 maint: multiple names: authors list (. The children later developed kidney failure and died. Promotes uniform dispersion; translucent to clear. • As a cosurfactant in the formation of microemulsions. The agency also identified urinary DEG as a biomarker for DEG exposures. [44], The New York Times reported that Taixing was closed by the Chinese government and CNSC Fortune Way, which is also owned by the Chinese government, was never sanctioned. BlmSchV (Hazardous Incident Ordinance) All the children had received acetaminophen syrup to treat upper respiratory infections related with malaria. Soon, patients from other parts of the country started to arrive at hospitals. DIETHYLENE GLYCOL MONOBUTYL ETHER 9TB90IYC0E Overview Structure Names 10: Classification 1: Identifiers 9: Relationships 1: Active Moiety 1: Audit Info References 15: Moieties 1: Substance Class: Chemical Record UNII: 9TB90IYC0E. Diethylene glycol (DEG) is an organic compound with the formula (HOCH2CH2)2O. I, the copyright holder of this work, hereby publish it under the following licenses: Austrian wine was banned in many countries and the U.S. Bureau of Alcohol, Tobacco and Firearms started to test all imported wine. Nearly half of the victims were under the age of two. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. Bureau of Alcohol, Tobacco, and Firearms. Lead CDC investigator Dr. Katherine O'Brien conducted a case-control investigation, looking for potential clues to the epidemic. [3] The toothpaste was labeled as “Manufactured in South Africa” and contained misspellings like "isclinically", "SOUTH AFRLCA" and "South African Dental Assoxiation". Once verifying that he was fine, he shipped it to Qiquihar No. Some wines contained less than 10 parts per million of DEG, a small amount that could not be detected by laboratory analysis in Europe. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. The regional drug controller authorities after investigation found out that a faulty batch of the Coldbest PC cough syrup contained 34.97% of diethylene glycol, which resulted in poisoning and subsequent renal failures. 2-(2-Butoxyethoxy)acetic acid was the major urinary metabolite with about 53% to … Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. Chemical Nomenclature. Reference: 1. 2 Pharmaceutical in 2005. [60] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. language of work or name. 17 November 2016. Diethylene glycol is one of several glycols derived from ethylene oxide. [42] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. After ingestion, DEG is absorbed through the gastrointestinal tract and distributed by the bloodstream throughout the body, reaching peak blood concentrations within 30 to 120 minutes. diethylene glycol monobutyl ether (English) retrieved. [1] DEG is a widely used solvent. stated in. They identified Tianhong Fine Chemicals Factory as the manufacturer. Because patients treated with Lisinopril developed a cough (a common side effect of ACE inhibitors), they were prescribed an expectorant. A wide variety of diethylene glycol monobutyl ether options are available to you, such as classification, grade standard, and usage. More commonly known as Diethylene Glycol Monoethyl Ether. The counterfeit syrup ended in ampules of Amillarisin A, a medication for gall bladder problems; special pediatric enema fluid; blood vessel disease injections; intravenous pain reliever; and an arthritis medication. [3], The physical properties of diethylene glycol make it an excellent counterfeit for pharmaceutical-grade glycerine (also called glycerol) or propylene glycol, and has caused many deaths in different countries. Synonyms and Related Terms. Records also revealed that to fool buyers, Wang falsified his license and laboratory analysis reports. The ether being relatively unreactive. of morpholine and 1,4-dioxane. [31], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. About 7% of these are Leather Auxiliary Agents, 47% are Alcohol & Hydroxybenzene & Ether, and 3% are Other Chemicals. [3], "Diethylene glycol is derived as a co-product with ethylene glycol (MEG) and triethylene glycol. Availability of DEG will depend on demand for derivatives of the primary product, ethylene glycol, rather than on DEG market requirements."[4]. [1][19][29][30], In Bangladesh between 1990 and 1992, 339 children developed kidney failure, and most of them died, after being given paracetamol (acetaminophen) syrup contaminated with diethylene glycol. In fact, the company bought the product in China and had already re-exported toothpaste to Costa Rica, Dominican Republic and Haiti, making Panama kick off a local warning. About Diethyl Glycol Monobutyl Ether Enquire Now. Once DEG reaches the liver, it is metabolized by enzymes. [8] The Australian government does not allow DEG as a food additive; it is only allowed at less than 0.25% w/w of DEG as an impurity of polyethylene glycol (PEG)[9] even in toothpaste. Diethylene glycol monobutyl ether agent detailed information in Haz-Map database. diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO 2. Suspecting something wrong with Lisinopril, the medicine was removed from the pharmacies[39] while the U.S. Food and Drug Administration conducted lab analyses, revealing the blood pressure drug was safe; CDC epidemiologists were then invited to participate. 17 November 2016. The symptoms seemed to match with Guillain–Barré syndrome, but these patients were also losing their ability to urinate, a symptom not related to Guillain–Barré. Shortly after, 2-hydroxyethoxyacetaldehyde (C4H8O3) is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the weak acid 2-hydroxyethoxyacetic acid (HEAA) with chemical formula C4H8O4. Butyl di glycol (also known as BDG, butyl dioxitol, diethylene glycol monobutyl ether, 2(-2butoxyethoxy) ethanol and butoxydiethylene glycol) is a colourless, clear organic compound with a faint characteristic odour that has the formula C 8 H 18 O 3.It is soluble in water and miscible with many common solvents, and also has low volatility and a high boiling point. The company tested the new product, Elixir Sulfanilamide, for viscosity, appearance and fragrance. [3] Because of its adverse effects on humans, diethylene glycol is not allowed for use in food and drugs. [39] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPhI worldwide (the world’s largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. [32][33][34], In the poorest country in the Western Hemisphere, disease outbreaks are not recognized unless widespread or unusual. While the FDA tried to find out Tianhong’s address, Chinese officials were reluctant to become involved. Details : Ethylene Glycol Monobutyl Ether. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. [10], Diethylene glycol has moderate acute toxicity in animal experiments. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. ", "Scandal over poisoned wine embitters village in Austria.". [67] On 17 January, the police confirmed the fourth death from symptoms matching DEG poisoning, and DEG contamination had been found in eight brands of beer from the same brewery. skin cream and lotions, deodorants), DEG is often replaced by selected diethylene glycol ethers. [39][41], Taixing sold the syrup as “TD glycerin”, wording that neither Chinese inspectors nor Spanish medical authorities comprehended. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Diethylene Glycol Monobutyl Ether Uses: This product is used primarily in the manufacturing of lacquers based on nitrocellulose, cellulose ethers and chlorinated rubber. [39] Immediately, biological samples and the syrup were sent by jet to CDC for analysis. Bogdanich, W. "Wider Sale Is Seen for Toothpaste Tainted in China ", U.S. Bureau of Alcohol, Tobacco and Firearms, Centers for Disease Control and Prevention, "Toxic alcohol ingestions: clinical features, diagnosis, and management", ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN: Polyethylene glycol, Existing Chemical Hazard Assessment Report, Australian Competition and Consumer Commission, "Toothpaste containing more than 0.25 per cent by weight of diethylene glycol (DEG)". Diethylene Glycol Monobutyl Ether poisoning symptoms, causes, diagnosis, and treatment information for Diethylene Glycol Monobutyl Ether poisoning (Chemical poisoning - Diethylene Glycol Monobutyl Ether) with alternative diagnoses, full-text book chapters, misdiagnosis, research … [26] The next year, an Austrian electric power plant (Österreichische Draukraftwerke) in Carinthia announced that technicians developed a way to produce energy through burning 30 million liters of contaminated wine. Diethylene Glycol Ether Factory Offer High Grade 99% Butyldiglycol/ Diethylene Glycol Monobutyl Ether Cas 112-34-5 US $2.00-$5.00 / Kilogram 1.0 Kilograms (Min Order) The prognosis depends on prompt diagnosis and treatment due to the high mortality rate DEG intoxication produces. Ethylene glycol is by far the largest volume of the glycol products in a variety of applications. English: Structure of Diethylene glycol monobutyl ether acetate. UNII. [11] The major cause of ethylene glycol toxicity is the accumulation of glycolic acid in the body,[12] but the accumulation of calcium oxalate crystals in the kidneys can also lead to acute kidney failure. Features. Some authors suggest the minimum toxic dose is estimated at 0.14 mg/kg of body weight and the lethal dose is between 1.0 and 1.63 g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1 mL/kg,[1] and others suggest this is the LD30. [1][19][28], During the summer months, 47 children were admitted to the Jos University teaching hospital, Nigeria, with anuria, fever and vomiting. Once physicians identified a suspect paracetamol syrup, samples were shipped to the Centers for Disease Control and Prevention (CDC) in the U.S., which identified DEG. 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